Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patterns of brain activation in people at risk for Alzheimer's disease.

The New England journal of medicine - 17 Aug 2000

Bookheimer S Y, Strojwas M H, Cohen M S, Saunders A M, Pericak-Vance M A, Mazziotta J C, Small G W

Abstract excerpt

BACKGROUND: The epsilon4 allele of the apolipoprotein E gene (APOE) is the chief known genetic risk factor for Alzheimer's disease, the most common cause of dementia late in life. To determine the relation between brain responses to tasks requiring memory and the genetic risk of Alzheimer's disease, we performed APOE genotyping and functional magnetic resonance imaging (MRI) of the brain in older persons with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E3
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Brain Mapping

Share to Hippocampus

Share to Image Processing, Computer-Assisted

Share to Memory

Share to Neuropsychological Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 10944562
DOI: 10.1056/NEJM200008173430701
PMCID: PMC2831477

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patterns of brain activation in people at risk for Alzheimer's disease.PMID 10944562Read ↗

Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.Semantic proximity Read ↗

Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele).Semantic proximity Read ↗

Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's disease: a cross-sectional study.Semantic proximity Read ↗

Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele.Semantic proximity Read ↗

Specificity of brain activation patterns in people at genetic risk for Alzheimer disease.Semantic proximity Read ↗

Reduced functional brain activity response in cognitively intact apolipoprotein E epsilon4 carriers.Semantic proximity Read ↗

APOE related alterations in cerebral activation even at college age.Semantic proximity Read ↗

Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults.Semantic proximity Read ↗

APOE ɛ4, but not polygenic Alzheimer's disease risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individuals.Semantic proximity Read ↗

APOE ɛ4, but not polygenic AD risk, is related to longitudinal decrease in hippocampal brain activity in non-demented individualsSemantic proximity Read ↗

fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease.Semantic proximity Read ↗

Better memory and neural efficiency in young apolipoprotein E epsilon4 carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.