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Article

Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele).

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Jan 2000

Scarmeas Nikolaos, Habeck Christian, Anderson Karen E, Hilton John, Devanand Davangere P, Pelton Gregory H, Tabert Matthias H, Flynn Joseph, Park Aileen, Ciappa Alejandra, Tycko Benjamin, Stern Yaakov

Abstract excerpt

OBJECTIVE: Few previous studies have investigated the association between APOE genotype and brain activation during performance of cognitive tasks in healthy middle-aged and elderly subjects, and the results have been mixed. The authors investigated APOE-mediated differential brain activation in a group of healthy elderly subjects. METHODS: Using H215O positron emission tomography (PET), they imaged 32 healthy...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15545327
DOI: 10.1176/appi.ajgp.12.6.596
PMCID: PMC3025285

Genes

APOE

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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