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Article

Mitochondrial DNA deletion mutation levels are elevated in ALS brains.

Neuroreport - 3 Aug 2000

Dhaliwal G K, Grewal R P

Abstract excerpt

This study was performed to explore the potential role of mitochondrial DNA mutations in the neurodegenerative process in amyotrophic lateral sclerosis (ALS). Using a semi-quantitative assay, a common mitochondrial DNA deletion mutation (mt DNA4977) was assayed in brain tissue obtained from six sporadic ALS patients and compared to four controls. In each brain, levels of this mutation were measured in a brain...

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Share to Aged, 80 and over
Share to Amyotrophic Lateral Sclerosis
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to Gene Deletion

Share to Motor Cortex

Share to Nerve Degeneration

Share to Temporal Lobe

Source

Identifiers

PMID: 10943712
DOI: 10.1097/00001756-200008030-00032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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