Article
Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis.
Clinical epigenetics - 11 Sept 2020
Stoccoro Andrea, Smith Adam R, Mosca Lorena, Marocchi Alessandro, Gerardi Francesca, Lunetta Christian, Cereda Cristina, Gagliardi Stella, Lunnon Katie, Migliore Lucia, Coppedè Fabio
Abstract excerpt
BACKGROUND: Mitochondrial dysregulation and aberrant epigenetic mechanisms have been frequently reported in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), and several researchers suggested that epigenetic dysregulation in mitochondrial DNA (mtDNA) could contribute to the neurodegenerative process. We recently screened families with mutations in the major ALS causative genes, namely...
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