Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients

1 Oct 1995

Abstract excerpt

To determine if somatic mtDNA mutations might contribute to the neurodegeneration observed in Huntington's disease (HD), we quantitated the amount of the common mitochondrial 4977 nucleotide pair deletion (mtDNA4977) in cortex and putamen of HD patients and age-matched controls by the serial dilution-polymerase chain reaction method. Cortical deletion levels were analyzed in the temporal, frontal, and occipital...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Neurodegenerative Diseases
Share to Mitochondrial Function and Pathology
Share to Neurological disorders and treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7477986
DOI: 10.1212/wnl.45.10.1879

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patientsPMID 7477986Read ↗

Mitochondrial DNA deletion mutation levels are elevated in ALS brains.Semantic proximity Read ↗

Selective striatal mtDNA depletion in end-stage Huntington's disease R6/2 mice.Semantic proximity Read ↗

Reduction in mitochondrial DNA copy number in peripheral leukocytes after onset of Huntington's diseaseSemantic proximity Read ↗

Quantification of total mitochondrial DNA and mitochondrial common deletion in the frontal cortex of patients with schizophrenia and bipolar disorder.Semantic proximity Read ↗

Huntington's disease and mitochondrial DNA deletions: event or regular mechanism for mutant huntingtin protein and CAG repeats expansion?!Semantic proximity Read ↗

Deleted 4977-bp mitochondrial DNA mutation is associated with sporadic amyotrophic lateral sclerosis: a hospital-based case-control study.Semantic proximity Read ↗

The 'common deletion' is not increased in parkinsonian substantia nigra as shown by competitive polymerase chain reaction.Semantic proximity Read ↗

Quantitation of a mitochondrial DNA deletion in Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.