Article
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004
Coskun Pinar E, Beal M Flint, Wallace Douglas C
Abstract excerpt
Defects in mitochondrial oxidative phosphorylation have frequently been associated with Alzheimer's disease (AD), and both inherited and somatic mtDNA mutations have been reported in certain AD cases. To determine whether mtDNA mutations contribute more generally to the etiology of AD, we have investigated the sequence of the mtDNA control region (CR) from AD brains for possible disease-causing mutations....
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