Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer disease

22 Jun 2013

Abstract excerpt

OBJECTIVE: To identify a novel biochemical marker that precedes clinical symptoms in Alzheimer disease (AD). METHODS: Using quantitative polymerase chain reaction techniques, we measured circulating cell-free mitochondrial DNA (mtDNA) in cerebrospinal fluid (CSF) from study participants, selected from a cohort of 282 subjects, who were classified according to their concentrations of amyloid β1-42, total tau, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Dementia and Cognitive Impairment Research
Share to Mitochondrial Function and Pathology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23794434
DOI: 10.1002/ana.23955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Low cerebrospinal fluid concentration of mitochondrial DNA in preclinical Alzheimer diseasePMID 23794434Read ↗

Cerebrospinal Fluid Mitochondrial DNA in Rapid and Slow Progressive Forms of Alzheimer’s DiseaseSemantic proximity Read ↗

Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage.Semantic proximity Read ↗

Reduced cerebrospinal fluid mitochondrial DNA is a biomarker for early‐stage Parkinson's diseaseSemantic proximity Read ↗

Characterization of mitochondrial DNA quantity and quality in the human aged and Alzheimer’s disease brainSemantic proximity Read ↗

The Role of Mitochondrial genome abundance in Alzheimer’s DiseaseSemantic proximity Read ↗

Is Mitochondria DNA Variation a Biomarker for AD?Semantic proximity Read ↗

Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolitesSemantic proximity Read ↗

Post-mortem ventricular cerebrospinal fluid cell-free-mtDNA in neurodegenerative diseaseSemantic proximity Read ↗

Blood-Based mtDNA Quantification Indicates Population-Specific Differences Associated with Alzheimer’s Disease-Related RiskSemantic proximity Read ↗

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication.Semantic proximity Read ↗

Genetic basis of Alzheimer's dementia: role of mtDNA mutations.Semantic proximity Read ↗

Mitochondrial DNA Copy Numbers in Pyramidal Neurons are Decreased and Mitochondrial Biogenesis Transcriptome Signaling is Disrupted in Alzheimer's Disease HippocampiSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.