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Article

Mitochondrial DNA Rearrangement Spectrum in Brain Tissue of Alzheimer's Disease: Analysis of 13 Cases.

PloS one - 1 Jan 2016

Chen Yucai, Liu Changsheng, Parker William Davis, Chen Hongyi, Beach Thomas G, Liu Xinhua, Serrano Geidy E, Lu Yanfen, Huang Jianjun, Yang Kunfang, Wang Chunmei

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction may play a central role in the pathologic process of Alzheimer's disease (AD), but there is still a scarcity of data that directly links the pathology of AD with the alteration of mitochondrial DNA. This study aimed to provide a comprehensive assessment of mtDNA rearrangement events in AD brain tissue. PATIENTS AND METHODS: Postmortem frozen human brain cerebral cortex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27299301
DOI: 10.1371/journal.pone.0154582
PMCID: PMC4907522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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