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Article

Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome.

The American journal of pathology - 1 Dec 2000

Kuperwasser C, Hurlbut G D, Kittrell F S, Dickinson E S, Laucirica R, Medina D, Naber S P, Jerry D J

Abstract excerpt

Breast cancer is the most frequent tumor type among women in the United States and in individuals with Li-Fraumeni syndrome. The p53 tumor suppressor gene is altered in a large proportion of both spontaneous breast malignancies and Li-Fraumeni breast cancers. This suggests that loss of p53 can accelerate breast tumorigenesis, yet p53-deficient mice rarely develop mammary tumors. To evaluate the effect of p53 loss...

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Source

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Identifiers

PMID: 11106587
DOI: 10.1016/S0002-9440(10)64853-5
PMCID: PMC1885755

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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