Article
A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability.
Nature genetics - 1 Nov 2000
Healey C S, Dunning A M, Teare M D, Chase D, Parker L, Burn J, Chang-Claude J, Mannermaa A, Kataja V, Huntsman D G, Pharoah P D, Luben R N, Easton D F, Ponder B A
Abstract excerpt
Inherited mutations in the gene BRCA2 predispose carriers to early onset breast cancer, but such mutations account for fewer than 2% of all cases in East Anglia. It is likely that low penetrance alleles explain the greater part of inherited susceptibility to breast cancer; polymorphic variants in strongly predisposing genes, such as BRCA2, are candidates for this role. BRCA2 is thought to be involved in DNA...
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