Insights from three decades of BRCA1/2 modeling in mice.

Abstract excerpt

Since the discovery of the BRCA1 and BRCA2 (hereafter referred to as BRCA1/2) hereditary breast and ovarian cancer genes three decades ago, genetically engineered and patient-derived mouse models have been instrumental in advancing our understanding of BRCA1/2 biology, particularly their roles in normal development, tumor suppression and therapy response. Brca1/2-mutant mouse models and derivative cell lines have...

Topics

• Animals
• Mice
• Humans
• Female
• Disease Models, Animal
• BRCA2 Protein
• BRCA1 Protein
• Ovarian Neoplasms
• Breast Neoplasms
• Mutation
• Genes, BRCA2
• Genes, BRCA1