Article
Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism.
Molecular and cellular biology - 1 Sept 2000
She P, Shiota M, Shelton K D, Chalkley R, Postic C, Magnuson M A
Abstract excerpt
We used an allelogenic Cre/loxP gene targeting strategy in mice to determine the role of cytosolic phosphoenolpyruvate carboxykinase (PEPCK) in hepatic energy metabolism. Mice that lack this enzyme die within 3 days of birth, while mice with at least a 90% global reduction of PEPCK, or a liver-specific knockout of PEPCK, are viable. Surprisingly, in both cases these animals remain euglycemic after a 24-h fast....
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