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Article

Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.

The Journal of biological chemistry - 18 Nov 2005

Yang Jianqi, Croniger Colleen M, Lekstrom-Himes Julie, Zhang Pu, Fenyus Maris, Tenen Daniel G, Darlington Gretchen J, Hanson Richard W

Abstract excerpt

Although CCAAT/enhancer-binding protein alpha (C/EBPalpha) is essential for initiating or sustaining several metabolic processes during the perinatal period, the consequences of total ablation of C/EBPalpha during postnatal development have not been investigated. We have created a conditional knock-out model in which the administration of poly(I:C) caused a virtually total deletion of c/ebpalpha...

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Source

Identifiers

PMID: 16166091
DOI: 10.1074/jbc.M503486200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.PMID 16166091Read ↗

Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.Semantic proximity Read ↗

CCAAT/enhancer binding protein alpha (C/EBPalpha) is an important mediator of mouse C/EBPbeta protein isoform production.Semantic proximity Read ↗

Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta have an attenuated response to cAMP and impaired carbohydrate metabolism.Semantic proximity Read ↗

C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue.Semantic proximity Read ↗

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha.Semantic proximity Read ↗

Disruption of hepatic C/EBPalpha results in impaired glucose tolerance and age-dependent hepatosteatosis.Semantic proximity Read ↗

Hepatic CCAAT/enhancer binding protein alpha mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice.Semantic proximity Read ↗

CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma.Semantic proximity Read ↗

Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscleSemantic proximity Read ↗

Lung-specific inactivation of CCAAT/enhancer binding protein α causes a pathological pattern characteristic of COPDSemantic proximity Read ↗

Effect of a C/EBP gene replacement on mitochondrial biogenesis in fat cells.Semantic proximity Read ↗

C/EBPalpha is critical for the neonatal acute-phase response to inflammation.Semantic proximity Read ↗

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