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Article

Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.

PloS one - 1 Jan 2012

Garcia Matthew, Leonardi Roberta, Zhang Yong-Mei, Rehg Jerold E, Jackowski Suzanne

Abstract excerpt

Pantothenate kinase (PanK) phosphorylates pantothenic acid (vitamin B(5)) and controls the overall rate of coenzyme A (CoA) biosynthesis. Pank1 gene deletion in mice results in a metabolic phenotype where fatty acid oxidation and gluconeogenesis are impaired in the fasted state, leading to mild hypoglycemia. Inactivating mutations in the human PANK2 gene lead to childhood neurodegeneration, but Pank2 gene...

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Share to Coenzyme A
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22815849
DOI: 10.1371/journal.pone.0040871
PMCID: PMC3398950

Genes

PANK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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