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Article

Murine Brca1: sequence and significance for human missense mutations.

Human molecular genetics - 1 Dec 1995

Sharan S K, Wims M, Bradley A

Abstract excerpt

We have cloned and sequenced a mouse homologue of the human breast and ovarian cancer susceptibility gene, BRCA1. The predicted mouse Brca1 protein is composed of 1812 amino acids. The murine protein is 60% identical and 72% similar to the human BRCA1 protein. Two regions of high homology have be...

Topics

Amino Acid Sequence
Animals
BRCA1 Protein
Base Sequence
Biological Evolution
Breast Neoplasms
Conserved Sequence
DNA, Complementary
Humans
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Proteins

RNA, Messenger

Sequence Homology, Amino Acid

Transcription Factors

Source

Identifiers

PMID: 8634698
DOI: 10.1093/hmg/4.12.2275

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8634698-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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