Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway.

The Journal of biological chemistry - 17 Nov 2000

Kao S Y, Lemoine F J, Marriott S J

Abstract excerpt

The Tax protein of human T cell leukemia virus type 1 is a viral transactivator and transforming protein. Tax is known to suppress cellular nucleotide excision repair (NER), and this activity has been proposed to play an important role in Tax transformation. In this study we have investigated the mechanism by which Tax suppresses NER with specific focus on the previously characterized ability of Tax to inhibit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to Gene Products, tax
Share to Genes, Reporter

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human T-lymphotropic virus 1

Share to Proliferating Cell Nuclear Antigen

Share to Proto-Oncogene Proteins p21(ras)

Share to Transcriptional Activation

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 10931836
DOI: 10.1074/jbc.M004397200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway.PMID 10931836Read ↗

Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression.Semantic proximity Read ↗

Human T-cell leukemia virus type 1 Tax relieves repression of proliferating cell nuclear antigen gene expression.Semantic proximity Read ↗

Human T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.Semantic proximity Read ↗

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Semantic proximity Read ↗

Molecular mechanisms of cellular transformation by HTLV-1 Tax.Semantic proximity Read ↗

P53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway.Semantic proximity Read ↗

Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Semantic proximity Read ↗

SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 TranscriptionSemantic proximity Read ↗

HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?Semantic proximity Read ↗

Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1.Semantic proximity Read ↗

p53-dependent down-regulation of telomerase is mediated by p21waf1.Semantic proximity Read ↗

Differences in the Ability of Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) and HTLV-2 Tax To Inhibit p53 FunctionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.