Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression.

AIDS research and human retroviruses - 1 Nov 2000

Lemoine F J, Kao S Y, Marriott S J

Abstract excerpt

The human T cell leukemia virus type 1 (HTLV-1) viral oncoprotein Tax acts as a transcriptional trans-activator affecting viral as well as cellular gene expression. To understand how Tax induces transformation, the consequences of its ability to alter expression of cellular genes must be examined. We have previously demonstrated that Tax activates expression of the cellular gene, proliferating cell nuclear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair
Share to Fibroblasts
Share to Gene Products, tax

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Human T-lymphotropic virus 1

Share to Plasmids

Share to Proliferating Cell Nuclear Antigen

Share to Transcriptional Activation

Share to Transfection

Source

Identifiers

PMID: 11080801
DOI: 10.1089/08892220050193056

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of DNA repair by HTLV type 1 Tax correlates with Tax trans-activation of proliferating cell nuclear antigen gene expression.PMID 11080801Read ↗

Human T-cell leukemia virus type 1 Tax relieves repression of proliferating cell nuclear antigen gene expression.Semantic proximity Read ↗

Suppression of DNA repair by human T cell leukemia virus type 1 Tax is rescued by a functional p53 signaling pathway.Semantic proximity Read ↗

Molecular mechanisms of cellular transformation by HTLV-1 Tax.Semantic proximity Read ↗

HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase.Semantic proximity Read ↗

Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes.Semantic proximity Read ↗

Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes.Semantic proximity Read ↗

Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells.Semantic proximity Read ↗

HIV-1 Tat and AIDS-associated cancer: targeting the cellular anti-cancer barrier?Semantic proximity Read ↗

Tax-dependent displacement of nucleosomes during transcriptional activation of human T-cell leukemia virus type 1.Semantic proximity Read ↗

Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.Semantic proximity Read ↗

Mutational analysis of the HTLV-I trans-activator, Tax.Semantic proximity Read ↗

Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.