Article
A novel stepwise analysis procedure of genome-wide expression profiles identifies transcript signatures of thiamine genes as classifiers of mitochondrial mutants.
Yeast (Chichester, England) - 1 Feb 2008
Eijssen L M T, Lindsey P J, Peeters R, Westra R L, van Eijsden R G E, Bolotin-Fukuhara M, Smeets H J M, Vlietinck R F M
Abstract excerpt
To extract functional information on genes and processes from large expression datasets, analysis methods are required that can computationally deal with these amounts of data, are tunable to specific research questions, and construct classifiers that are not overspecific to the dataset at hand. To satisfy these requirements, a stepwise procedure that combines elements from principal component analysis and...
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