Article
[Mutations of APC gene MCR region in sporadic colorectal adenomas and carcinomas].
Zhonghua zhong liu za zhi [Chinese journal of oncology] - 1 Jul 1998
Wang Y, Liu S, Hao D
Abstract excerpt
OBJECTIVE: Fifteen specimens of colorectal adenomas and 45 specimens of carcinomas and each of their normal mucosa were analyzed for the APC gene exon 15 MCR(mutation cluster region). METHODS: Gene mutation was examined by PCR-SSCP technique. RESULTS: In three out of 15 cases of adenomas(20.0%) and 10 out of 45 cases of carcinomas(22.2%), mutations at MCR was detected. In colorectal carcinoma, APC gene mutation...
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