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Article

Different phenotype manifestation of familial adenomatous polyposis in families with APC mutation at codon 1309.

Neoplasma - 1 Jan 2009

Wachsmannova-Matelova L, Stevurkova V, Adamcikova Z, Holec V, Zajac V

Abstract excerpt

Germline mutation in APC gene induced development of familial adenomatous polyposis (FAP). The risk of developing specific manifestation of FAP is often correlated with the position of the inherited APC mutation. Patients with mutations localized in the largest exon 15 between codons 1286 and 1513 (mutation cluster region, MCR) have generally a worse prognosis with early onset of the disease. We found 6 FAP...

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Source

Identifiers

PMID: 19728755
DOI: 10.4149/neo_2009_06_486

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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