APC mutations in human colorectal adenomas: analysis of the mutation cluster region with temperature gradient gel electrophoresis and clinicopathological features.

doi:10.1002/(SICI)1096-9896(199808)185:4<360::AID-PATH120>3.0.CO;2-O

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Article

APC mutations in human colorectal adenomas: analysis of the mutation cluster region with temperature gradient gel electrophoresis and clinicopathological features.

The Journal of pathology - 1 Aug 1998

Mulkens J, Poncin J, Arends J W, De Goeij A F

Abstract excerpt

To date, the earliest mutations in colorectal adenomas have been found in the adenomatous polyposis coli (APC) gene, considered the 'gatekeeper' in tumourigenesis. To study the types of APC gene mutations and their relation to clinicopathological features which are associated with malignant poten...

Topics

Adenoma
Colorectal Neoplasms
Electrophoresis, Polyacrylamide Gel
Genes, APC
Humans
Mutation
Polymerase Chain Reaction
Reproducibility of Results
Sensitivity and Specificity

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