Article
Mutation analysis of APC gene in gastric cancer with microsatellite instability.
World journal of gastroenterology - 1 Oct 2002
Fang Dian-Chun, Luo Yuan-Hui, Yang Shi-Ming, Li Xiao-An, Ling Xian-Long, Fang Li
Abstract excerpt
AIM: To evaluate the role of APC mutation in gastric carcinogenesis and to correlate APC mutation with microsatellite instability (MSI) in gastric carcinomas. METHODS: APC mutation was measured with multiplex PCR, denaturing gradient gel electrophoresis and DNA sequencing; and MSI was analyzed by PCR-based methods. RESULTS: Sixty-eight cases of sporadic gastric carcinoma were studied for APC mutation at exon 15...
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