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Article

Detection of tumor mutations in the presence of excess amounts of normal DNA.

Nature biotechnology - 1 Feb 2002

Sun Xiyuan, Hung K, Wu L, Sidransky D, Guo Baochuan

Abstract excerpt

Mutations are important markers in the early detection of cancer. Clinical specimens such as bodily fluid samples often contain a small percentage of mutated cells in a large background of normal cells. Thus, assays to detect mutations leading to cancer need to be highly sensitive and specific. In addition, they should be possible to carry out in an automated and high-throughput manner to allow large-scale...

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PMID: 11821866
DOI: 10.1038/nbt0202-186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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