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Article

Mutational spectrometry without phenotypic selection: human mitochondrial DNA.

Nucleic acids research - 15 Feb 1997

Khrapko K, Coller H, André P, Li X C, Foret F, Belenky A, Karger B L, Thilly W G

Abstract excerpt

By first separating mutant from nonmutant DNA sequences on the basis of their melting temperatures and then increasing the number of copies by high-fidelity DNA amplification, we have developed a method that allows observation of point mutations in biological samples at fractions at or above 10-6...

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Share to Cell Line
Share to DNA, Mitochondrial
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoresis, Polyacrylamide Gel

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Share to Polymerase Chain Reaction

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Source

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Identifiers

PMID: 9016616
DOI: 10.1093/nar/25.4.685
PMCID: PMC146488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9016616-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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