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Article

Mutations in Bacillus subtilis PyrR, the pyr regulatory protein, with defects in regulation by pyrimidines.

FEMS microbiology letters - 15 Mar 1996

Ghim S Y, Switzer R L

Abstract excerpt

The pyrimidine nucleotide biosynthetic (pyr) operon in Bacillus subtilis is regulated by a transcriptional attenuation mechanism in which PyrR, a bifunctional pyr RNA-binding attenuation protein/uracil phosphoribosyltransferase, plays a crucial role. A convenient procedure for isolation of pyrR mutants with defects in the regulation of pyr operon expression is described. The selection is based on the selection of...

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PMID: 8935652
DOI: 10.1111/j.1574-6968.1996.tb08075.x

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