Article
Allelic losses demonstrate monoclonality of multifocal bladder tumors.
International journal of cancer - 15 Aug 2000
Louhelainen J, Wijkström H, Hemminki K
Abstract excerpt
The clonality of multifocal bladder tumors has been studied over the years with some controversial results. We have examined 5 patients with 2-11 low-grade superficial multifocal bladder tumors for loss of heterozygosity (LOH) at 87 loci on 9 chromosomes. When LOH was detected at a given marker, the tumors consistently showed deletion of a specific allele, suggesting the monoclonality of the patients' tumors. No...
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