Article
Bladder cancer genotype stability during clinical progression.
Genes, chromosomes & cancer - 1 Sept 2000
Tsao J L, Yatabe Y, Markl I D, Hajyan K, Jones P A, Shibata D
Abstract excerpt
Genomic instability is manifested by the accumulation of large numbers of mutations. The rate at which mutations accumulate has been difficult to estimate because serial comparisons are required. For further insight into how quickly mutations accumulate during clinical progression, cell lines sequentially isolated 6 or 11 months apart from two patients with metastatic bladder cancer were compared for loss of...
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