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Article

Evidence for Polyclonal Origin of Multifocal Clear Cell Renal Cell Carcinoma

15 Dec 2008

Abstract excerpt

PURPOSE: Renal cell carcinomas are often multifocal. We investigated the genomic signatures of multifocal clear cell renal cell carcinoma to determine whether multiple tumors in the same kidney bear a clonal relationship to one another. EXPERIMENTAL DESIGN: A total of 62 tumors from 26 patients who underwent radical nephrectomy were examined. All patients had multiple separate clear cell renal carcinomas. Loss of...

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PMID: 19088024
DOI: 10.1158/1078-0432.ccr-08-1494

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