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Article

Analysis of genetic events in 17p13 and 9p21 regions supports predominant monoclonal origin of multifocal and recurrent bladder cancer.

Cancer letters - 8 Oct 2006

Trkova Marie, Babjuk Marko, Duskova Jaroslava, Benesova-Minarikova Lucie, Soukup Viktor, Mares Jaroslav, Minarik Marek, Sedlacek Zdenek

Abstract excerpt

Clonality was tested in 86 tumours from 25 patients with recurrent and multifocal superficial bladder transitional cell carcinomas (TCCs) using the analysis of TP53 mutations and of LOH in the 17p13 and 9p21 regions. Tumours from the majority of individuals showed either absence or presence of the same TP53 mutation and/or an identical LOH pattern, with the same allele lost in all tumours. Only two pairs of...

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Share to Antibodies, Monoclonal
Share to Carcinoma, Transitional Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Chromosomes, Human, Pair 9

Share to Loss of Heterozygosity

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Share to Tumor Suppressor Protein p53

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Source

Identifiers

PMID: 16343743
DOI: 10.1016/j.canlet.2005.10.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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