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Article

Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 May 2006

Kuwajima Takaaki, Nishimura Isao, Yoshikawa Kazuaki

Abstract excerpt

Necdin, a member of the MAGE (melanoma antigen) protein family, is expressed predominantly in terminally differentiated neurons. The necdin gene NDN is maternally imprinted and expressed only from the paternal allele, the deficiency of which is implicated in the pathogenesis of the neurodevelopmental disorder Prader-Willi syndrome. Necdin binds to its homologous MAGE protein MAGE-D1 (also known as NRAGE or...

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Identifiers

PMID: 16707790
DOI: 10.1523/JNEUROSCI.1262-06.2006
PMCID: PMC6675313

Genes

NDN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins.PMID 16707790Read ↗

Necdin, a Prader-Willi syndrome candidate gene, regulates gonadotropin-releasing hormone neurons during developmentSemantic proximity Read ↗

Expression and imprinting of MAGEL2 suggest a role in Prader-willi syndrome and the homologous murine imprinting phenotype.Semantic proximity Read ↗

Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression.Semantic proximity Read ↗

NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression.Semantic proximity Read ↗

Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons.Semantic proximity Read ↗

The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and MouseSemantic proximity Read ↗

The mouse Necdin gene is expressed from the paternal allele only and lies in the 7C region of the mouse chromosome 7, a region of conserved synteny to the human Prader-Willi syndrome region.Semantic proximity Read ↗

Draxin Inhibits Axonal Outgrowth through the Netrin Receptor DCCSemantic proximity Read ↗

A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.Semantic proximity Read ↗

The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.Semantic proximity Read ↗

A necdin/MAGE-like gene in the chromosome 15 autism susceptibility region: expression, imprinting, and mapping of the human and mouse orthologues.Semantic proximity Read ↗

The human necdin gene, NDN, is maternally imprinted and located in the Prader-Willi syndrome chromosomal regionSemantic proximity Read ↗

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