Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Aug 2008

Hasegawa Koichi, Yoshikawa Kazuaki

Abstract excerpt

Sirtuin1 (Sirt1), a mammalian homolog of yeast Sir2, deacetylates the tumor suppressor protein p53 and attenuates p53-mediated cell death. Necdin, a p53-interacting protein expressed predominantly in postmitotic neurons, is a melanoma antigen family protein that promotes neuronal differentiation and survival. In mammals, the necdin gene (Ndn) is maternally imprinted, and mutant mice carrying mutated paternal Ndn...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Carcinoma
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred ICR

Share to Organ Culture Techniques

Share to Prosencephalon

Share to Sirtuin 1

Share to Sirtuins

Source

Open in PubMed Open full text

Identifiers

PMID: 18753379
DOI: 10.1523/JNEUROSCI.3052-08.2008
PMCID: PMC6670824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons.PMID 18753379Read ↗

Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.Semantic proximity Read ↗

Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons.Semantic proximity Read ↗

Functional domains of necdin for protein-protein interaction, nuclear matrix targeting, and cell growth suppression.Semantic proximity Read ↗

NSCL-1 and NSCL-2 synergistically determine the fate of GnRH-1 neurons and control necdin gene expression.Semantic proximity Read ↗

Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins.Semantic proximity Read ↗

The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm.Semantic proximity Read ↗

Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cellsSemantic proximity Read ↗

Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA DamageSemantic proximity Read ↗

The Necdin Gene is Deleted in Prader-Willi Syndrome and is Imprinted in Human and MouseSemantic proximity Read ↗

The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle ArrestSemantic proximity Read ↗

Identification of ANKRD11 as a p53 coactivator.Semantic proximity Read ↗

Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.