Article
Idiopathic hyperaldosteronism: analysis of aldosterone synthase gene.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jun 2000
Miyamori I, Inaba S, Hatakeyama H, Taniguchi N, Takeda Y
Abstract excerpt
We analyzed the CYP11B2, the gene encoding aldosterone synthase, in mononuclear leukocytes in eight patients with primary aldosteronism due to zona glomerulosa hyperplasia (idiopathic hyperaldosteronism) and compared the results with aldosterone-producing adenomas. In idiopathic hyperaldosteronism, aldosterone synthase activity was significantly increased in accordance with gene expression (P < 0.05), compared...
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