Article
The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation.
Molecular and cellular endocrinology - 31 Mar 2004
Connell John M C, Fraser Robert, MacKenzie Scott M, Friel Elaine C, Ingram Mary C, Holloway Christine D, Davies Eleanor
Abstract excerpt
The terminal stages in the synthesis of aldosterone and cortisol are catalysed by the enzymes aldosterone synthase and 11beta-hydroxylase respectively. We have previously reported that polymorphic variation in the 5' promoter region (-344C/T) of the gene encoding aldosterone synthase (CYP11B2) is associated with increased aldosterone metabolite excretion and with hypertension associated with a raised aldosterone...
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