Structural analysis and evaluation of the aldosterone synthase gene in hypertension.

doi:10.1161/01.hyp.32.2.198

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Article

Structural analysis and evaluation of the aldosterone synthase gene in hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 1998

Brand E, Chatelain N, Mulatero P, Féry I, Curnow K, Jeunemaitre X, Corvol P, Pascoe L, Soubrier F

Abstract excerpt

Anomalies in either of the tightly linked genes encoding the enzymes CYP11B1 (11beta-hydroxylase) or CYP11B2 (aldosterone synthase) can lead to important changes in arterial pressure and are responsible for several monogenically inherited forms of hypertension. Mutations in these genes or their r...

Topics

Adult
Cytochrome P-450 CYP11B2
Female
Gene Frequency
Genetic Linkage
Humans
Hypertension
Male
Middle Aged
Mutation
Polymorphism, Genetic

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