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Article

A megalin polymorphism associated with promoter activity and Alzheimer's disease risk.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2010

Vargas Teo, Bullido Maria Jesus, Martinez-Garcia Ana, Antequera Desiree, Clarimon Jordi, Rosich-Estrago Marcel, Martin-Requero Angeles, Mateo Ignacio, Rodriguez-Rodriguez Eloy, Vilella-Cuadrada Elisabet, Frank Ana, Lleo Alberto, Molina-Porcel Laura, Blesa Rafael, Combarros Onofre, Gomez-Isla Teresa, Bermejo-Pareja Felix, Valdivieso Fernando, Carro Eva

Abstract excerpt

Elevated cerebral levels of amyloid beta-protein (Abeta) occur in Alzheimer's disease (AD), yet only a few patients show evidence of increased Abeta production. This observation suggests that many, perhaps most, cases of AD are caused by faulty clearance of Abeta. Megalin, which plays an importan...

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Identifiers

PMID: 20052685
DOI: 10.1002/ajmg.b.31056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20052685-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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