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Article

Cooperation of DEF6 with activated Rac in regulating cell morphology.

The Journal of biological chemistry - 19 Jan 2007

Oka Tsutomu, Ihara Sayoko, Fukui Yasuhisa

Abstract excerpt

Rho-family GTPases have been implicated in actin remodeling and subsequent morphologic changes in various cells. DEF6, a pleckstrin homology domain-containing protein, has been reported to regulate Rho-family GTPases as a guanine nucleotide exchange factor. Here, we demonstrate that DEF6 also has the property of cooperating with activated Rac1. DEF6 bound selectively to Rac1 loaded with GTP. The interaction is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

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Source

Identifiers

PMID: 17121847
DOI: 10.1074/jbc.M605153200

Genes

DEF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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