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Article

The Apaf-1 internal ribosome entry segment attains the correct structural conformation for function via interactions with PTB and unr.

Molecular cell - 1 Mar 2003

Mitchell Sally A, Spriggs Keith A, Coldwell Mark J, Jackson Richard J, Willis Anne E

Abstract excerpt

We have shown previously that polypyrimidine tract binding protein 1 (PTB) binds and activates the Apaf-1 internal ribosome entry segment (IRES) when the protein upstream of N-ras (unr) is prebound. Here we show that the Apaf-1 IRES is highly active in neuronal-derived cell lines due to the presence of the neuronal-enhanced version of PTB, nPTB. The unr and PTB/nPTB binding sites have been located on the Apaf-1...

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PMID: 12667457
DOI: 10.1016/s1097-2765(03)00093-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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