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Article

Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein.

The Journal of biological chemistry - 25 Mar 2011

Tang Zhen Zhi, Sharma Shalini, Zheng Sika, Chawla Geetanjali, Nikolic Julia, Black Douglas L

Abstract excerpt

CaV1.2 calcium channels play roles in diverse cellular processes such as gene regulation, muscle contraction, and membrane excitation and are diversified in their activity through extensive alternative splicing of the CaV1.2 mRNA. The mutually exclusive exons 8a and 8 encode alternate forms of transmembrane segment 6 (IS6) in channel domain 1. The human genetic disorder Timothy syndrome is caused by mutations in...

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Identifiers

PMID: 21282112
DOI: 10.1074/jbc.M110.208116
PMCID: PMC3060452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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