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Article

Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?

Genes & development - 1 Mar 1991

Black D L

Abstract excerpt

The neuron-specific splicing of the mouse c-src N1 exon was analyzed. Model src genes, transiently expressed in HeLa and LA-N-5 neuroblastoma cells, were assayed for the insertion of the 18-nucleotide neuron-specific N1 exon into their product mRNA. The normal clone fails to use this exon in HeLa cells but inserts the exon into 50% of the mature mRNA in LA-N-5 cells. When the exon and flanking intron sequences...

Topics

Animals
Base Sequence
Chickens
Exons
Genes, src
HeLa Cells
Humans
Mice
Molecular Sequence Data
Mutation
Neuroblastoma
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

RNA Splicing

Restriction Mapping

Tumor Cells, Cultured

Source

Identifiers

PMID: 2001841
DOI: 10.1101/gad.5.3.389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2001841-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Does steric interference between splice sites block the splicing of a short c-src neuron-specific exon in non-neuronal cells?PMID 2001841Read ↗

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