Article
Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro.
Cell - 29 May 1992
Black D L
Abstract excerpt
A conserved positive-acting RNA sequence was found to be required for the neuron-specific splicing of the mouse c-src N1 exon. The sequence lies in the intron between exons N1 and 4, close to the N1 donor site. Normally, only the neural-specific splicing of exon N1 required this sequence. When the intron downstream of N1 was shortened, splicing at the constitutive exon 4 acceptor also became dependent on the...
Topics
- Animals
- Base Sequence
- Cell Extracts
- Exons
- Genes, src
- Introns
- Mice
- Molecular Sequence Data
- Mutation
- Neurons
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction