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Article

[Methylene tetrahydrofolate reductase mutations as genetic risk factors for neural tube defects (NTF)].

Medycyna wieku rozwojowego - 1 Jan 2000

Mierzejewska E

Abstract excerpt

Folic acid supplementation before conception and during the first trimester of pregnancy prevents about 70% of all neural tube defects (NTD). Folic acid is a cofactor in the homocysteine metabolism. Its product--S-adenosylmethionine is a major methyl donor for reactions taking place in a cell. The 677 C-->T mutation in the methylene tetrahydrofolate reductase gene leads to thermolability and decreased activity of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10910677

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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[Methylene tetrahydrofolate reductase mutations as genetic risk factors for neural tube defects (NTF)].PMID 10910677Read ↗

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