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Article

A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects.

QJM : monthly journal of the Association of Physicians - 1 Nov 1995

Whitehead A S, Gallagher P, Mills J L, Kirke P N, Burke H, Molloy A M, Weir D G, Shields D C, Scott J M

Abstract excerpt

It is now well-established that folic acid, taken peri-conceptionally, can reduce the risk of neural tube defects (NTDs). Recent work has demonstrated that an abnormality of homocysteine metabolism is a critical factor. The gene for 5,10 methylenetetrahydrofolate reductase, an enzyme important in homocysteine metabolism, was studied in relation to NTDs. To determine the frequency of the allele for the...

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PMID: 8542260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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