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Article

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.

Science (New York, N.Y.) - 9 Feb 1996

Rawlings D J, Scharenberg A M, Park H, Wahl M I, Lin S, Kato R M, Fluckiger A C, Witte O N, Kinet J P

Abstract excerpt

Bruton's tyrosine kinase (BTK) is pivotal in B cell activation and development through its participation in the signaling pathways of multiple hematopoietic receptors. The mechanisms controlling BTK activation were studied here by examination of the biochemical consequences of an interaction between BTK and SRC family kinases. This interaction of BTK with SRC kinases transphosphorylated BTK on tyrosine at residue...

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Source

Identifiers

PMID: 8629002
DOI: 10.1126/science.271.5250.822

Genes

BTK
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases.PMID 8629002Read ↗

Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain-mediated interaction.Semantic proximity Read ↗

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Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.Semantic proximity Read ↗

Signalling of Bruton's Tyrosine Kinase, BtkSemantic proximity Read ↗

TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.Semantic proximity Read ↗

Four tyrosine residues in phospholipase C-gamma 2, identified as Btk-dependent phosphorylation sites, are required for B cell antigen receptor-coupled calcium signaling.Semantic proximity Read ↗

The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapySemantic proximity Read ↗

Bruton's tyrosine kinase controls a sustained calcium signal essential for B lineage development and function.Semantic proximity Read ↗

Role of Bruton’s tyrosine kinase in B cells and malignanciesSemantic proximity Read ↗

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