Article
Negative regulation of FcepsilonRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b.
Blood - 1 Mar 2004
Qu Xiujuan, Sada Kiyonao, Kyo Shinkou, Maeno Koichiro, Miah S M Shahjahan, Yamamura Hirohei
Abstract excerpt
Aggregation of the high-affinity immunoglobulin E (IgE) receptor (FcepsilonRI) on mast cells induces a number of biochemical events, including protein-tyrosine phosphorylation leading to degranulation and multiple cytokine gene transcription. Here, we have demonstrated that a second member of the Cbl family of ubiquitin-protein ligase Cbl-b translocates into the lipid raft after FcepsilonRI engagement....
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