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Article

Mutational analysis of bli-4/kpc-4 reveals critical residues required for proprotein convertase function in C. elegans.

Gene - 11 Jul 2000

Thacker C, Srayko M, Rose A M

Abstract excerpt

Kex2/subtilisin-like proteinase activity is required for the production of the adult cuticle in the nematode Caenorhabditis elegans. Deletion of the carboxy termini of four of the bli-4/kpc-4 convertase isoforms results in blistering of the adult cuticle. The blisters vary in severity (expressivity) and are not evident in all individuals (reduced penetrance). We have isolated 13 bli-4/kpc-4 mutants that arrest...

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PMID: 10903434
DOI: 10.1016/s0378-1119(00)00211-0

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