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Article

Embryonic lethality caused by mutations in basement membrane collagen of C. elegans.

Nature - 21 Feb 1991

Guo X D, Johnson J J, Kramer J M

Abstract excerpt

Basement membranes are specialized forms of extracellular matrix with important functions in development. A major structural component of basement membranes is type IV collagen, a heterotrimer of two alpha 1(IV) and one alpha 2(IV) chains, which forms a complex, polygonal network associated with other basement membrane components. Here we report that the alpha 1(IV) collagen chain of Caenorhabditis elegans is...

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PMID: 1996137
DOI: 10.1038/349707a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Embryonic lethality caused by mutations in basement membrane collagen of C. elegans.PMID 1996137Read ↗

Characterization of alpha1(IV) collagen mutations in Caenorhabditis elegans and the effects of alpha1 and alpha2(IV) mutations on type IV collagen distribution.Semantic proximity Read ↗

Structures and functions of collagens in Caenorhabditis elegans.Semantic proximity Read ↗

Mutations in the alpha 2(IV) basement membrane collagen gene of Caenorhabditis elegans produce phenotypes of differing severities.Semantic proximity Read ↗

The let-268 locus of Caenorhabditis elegans encodes a procollagen lysyl hydroxylase that is essential for type IV collagen secretion.Semantic proximity Read ↗

A complete collagen IV fluorophore knock-in toolkit reveals α-chain diversity in basement membraneSemantic proximity Read ↗

A collagen IV fluorophore knock-in toolkit reveals trimer diversity in C. elegans basement membranes.Semantic proximity Read ↗

Identification of epi-1 locus as a laminin alpha chain gene in the nematode Caenorhabditis elegans and characterization of epi-1 mutant alleles.Semantic proximity Read ↗

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