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Article

Inactivation of Kex2p diminishes the virulence of Candida albicans.

The Journal of biological chemistry - 17 Jan 2003

Newport George, Kuo Alan, Flattery Amy, Gill Charles, Blake Julie J, Kurtz Myra B, Abruzzo George K, Agabian Nina

Abstract excerpt

Deletion of the kexin gene (KEX2) in Candida albicans has a pleiotropic effect on phenotype and virulence due partly to a defect in the expression of two major virulence factors: the secretion of active aspartyl proteinases and the formation of hyphae. kex2/kex2 mutants are highly attenuated in a mouse systemic infection model and persist within cultured macrophages for at least 24 h without causing damage....

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Identifiers

PMID: 12419804
DOI: 10.1074/jbc.M209713200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inactivation of Kex2p diminishes the virulence of Candida albicans.PMID 12419804Read ↗

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