KEX2 influences Candida albicans proteinase secretion and hyphal formation.

doi:10.1074/jbc.272.46.28954

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Article

KEX2 influences Candida albicans proteinase secretion and hyphal formation.

The Journal of biological chemistry - 14 Nov 1997

Newport G, Agabian N

Abstract excerpt

Candida albicans possesses at least seven differentially expressed genes that encode virulence-related secretory aspartyl proteinases (Saps). Sap DNA sequences predict post-translational processing at lysine-arginine residues in the preproteins, reminiscent of the maturation of Saccharomyces cerevisiae alpha-factor, where a prepropolypeptide is converted into a biologically active pheromone by Kex2, a...

Topics

Amino Acid Sequence
Aspartic Acid Endopeptidases
Base Sequence
Candida albicans
Cloning, Molecular
DNA, Fungal
Genetic Complementation Test
Killer Factors, Yeast
Mating Factor
Molecular Sequence Data
Mutation
Mycotoxins
Peptides
Proprotein Convertases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Subtilisins

Source

Open in PubMed

Identifiers

PMID: 9360967
DOI: 10.1074/jbc.272.46.28954

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