Article
Association of the I1307K APC mutation with hereditary and sporadic breast/ovarian cancer: more questions than answers.
British journal of cancer - 1 Jul 2000
Gershoni-Baruch R, Patael Y, Dagan, Figer A, Kasinetz L, Kadouri E, Bruchim Bar Sade R, Friedman E
Abstract excerpt
The frequency of the APC I1307K mutation and its association with disease pattern was examined in 996 Ashkenazi women consisting of individuals with either sporadic (n = 382) or hereditary (n = 143) breast and/or ovarian cancer; asymptomatic BRCA1/2 mutation carriers (185delAG, 5382insC and 6174delT) (n= 53) and healthy controls (n= 418). The I1307K allele was equally distributed among women with sporadic...
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