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Article

The effect of the I1307K APC polymorphism on the clinicopathological features and natural history of breast cancer.

British journal of cancer - 1 Nov 1999

Yuan Z Q, Bégin L R, Wong N, Brunet J S, Trifiro M, Gordon P H, Pinsky L, Foulkes W D

Abstract excerpt

The I1307K polymorphism in APC has been found to predispose to colorectal cancer in Ashkenazi Jews, and has recently been associated with an increased risk for breast cancer in the same population. In that study, we genotyped 205 paraffin-embedded breast cancers from Ashkenazi Jewish women diagnosed below the age of 65. We now present an extended analysis, with clinicopathological correlations between carriers of...

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Share to Adenomatous Polyposis Coli Protein
Share to Cytoskeletal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, APC

Share to Neoplasm Proteins

Share to Polymorphism, Single-Stranded Conformational

Share to Receptors, Estrogen

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 10555757
DOI: 10.1038/sj.bjc.6690775
PMCID: PMC2374295

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The effect of the I1307K APC polymorphism on the clinicopathological features and natural history of breast cancer.PMID 10555757Read ↗

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Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K: evidence of genetic drift within the Ashkenazim.Semantic proximity Read ↗

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